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Anti-malaria drug information : Artesunat
One of my friend just contacted me to found Arsen (artesunate), she contacted all hospital in my town for looking for arsen. One of her family was in hospital due to Cerebral Malaria. Then I tried to contacted my office, because I know they should have Artesunate on stock due to their services.
Artesunate is the newest preparation for malaria treatment, but it's only knew by a few doctor in Indonesia (my country, one of malaria' endemic area). I know about this medicine when I was in Tembagapura Hospital (Freeport Indonesia, Papua) in August 2009. We use artesunate for treat patient with malaria. I saw all patient that treat with this medicine had a quick improvement, then conventional medicine that we always use in other part of Indonesia. Due to that reasons, I try to find out some articles about artesunate. One of them I found in Wikipedia.com and I translate it in English.
Artesunate
Pharmacological Properties
Artesunate has a significantly improved compared with artemisinin bioavailability. Like all artemisinin derivatives, it acts on an endogenous peroxygen which presumably infected erythrocytes for Plasmodium toxic radicals formed. The problem is the relatively short half-life. Artesunate is in the liver by the enzyme CYP3A4 metabolised.
Preparations and use
Artesunate is used mainly as a combination drug with other agents such as malaria, amodiaquine for the treatment of malaria. An Artesunate-amodiaquine combination drug (ASAQ) was developed in cooperation between the Drugs for Neglected Diseases Initiative (DNDi) and Sanofi-aventis is developing and in several African countries. There are currently no Artesunate drugs approved in Europe for the ASAQ preparation but an authorization is sought, it should in the future under the brand name Coarsucam ®. Other combinations of Artesunate with Mefloquin are currently in development.
The focus for the application of Artesunate is the treatment of uncomplicated malaria tropica, Plasmodium in particular, against the other drugs such as chloroquine resistant. The World Health Organization does not recommend the use as a starting Monosubstanz to minimize the risk of resistance to artemisinin derivatives to decrease.
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Swine Flu Update : A summary of the general situation regarding the new human influenza A/H1N1 EPIDEMIOLOGICAL SITUATION
EPIDEMIOLOGICAL SITUATION AT THE INTERNATIONAL LEVEL
At international level, the new confirmed cases of influenza A/H1N1 in accordance with World Health Organization (WHO) and the Center of Disease Control (CDC) in Atlanta are a total of 27,743 and 141 deaths. In particular, Saudi Arabia 1 confirmed case and no, Argentina death: 235 confirmed cases and no deaths, Australia: 1224 confirmed cases and no deaths, Austria: 5 confirmed cases and no death, Bahamas: 2 confirmed case and no death, Bahrain: 1 confirmed case and no death, Barbados 2 confirmed cases and no deaths, Belgium: 14 confirmed cases and no deaths, Bolivia: 3 confirmed cases and no deaths, Brazil: 36 confirmed cases and no deaths, Bulgaria: 2 confirmed case no death, Cajman Islands 1 confirmed case and no death, Canada: 2446 confirmed cases and 4 deaths, Chile: 1694 cases confirmed and 2 deaths, China: 142 confirmed cases and no deaths, Colombia: 35 confirmed cases and no death, Costa Rica: 93 confirmed cases and 1 death, Cuba: 5 confirmed cases and no deaths, Cyprus: 1 confirmed case and no death, Denmark: 8 confirmed cases and no death, Dominica 1 confirmed case and no death, Egypt: 8 confirmed case no death, Ecuador: 60 confirmed cases and no death El Salvador: 69 confirmed cases and no death, UAE 1 confirmed case and no death, Estonia: 4 confirmed cases and no death, Philippines : 54 confirmed cases and no death, Finland: 4 confirmed cases and no death, France: 71 confirmed cases and no death, Germany: 78 confirmed cases and no death, Jamaica: 7 confirmed cases and no deaths, Japan: 485 confirmed cases and no deaths, Greece: 5 confirmed cases and no death, Guatemala: 89 confirmed cases and no death, Honduras: 34 confirmed cases and no death, India: 4 confirmed cases and no death, Ireland: 12 confirmed cases and no death, Iceland: 2 confirmed case and no death, Israel: 63 cases confirmed and no death, Italy: 58 confirmed cases and no deaths, Lebanon 8 confirmed cases and no death, Luxembourg 1 confirmed case and no death, Kuwait: 18 confirmed cases and no death, Malaysia: 5 confirmed cases and no death, Mexico: 5717 confirmed cases and 106 deaths, Nicaragua : 29 confirmed cases and no death, Norway: 9 confirmed cases and no death, New Zealand: 23 confirmed cases and no deaths, Netherlands: 22 confirmed cases and no deaths, Panama: 221 confirmed cases and no death, Paraguay: 16 confirmed cases and no death, Peru: 64 confirmed cases and no deaths, Poland: 6 confirmed cases and no death, Portugal: 2 confirmed cases and no deaths, United Kingdoms: 666 confirmed cases and no deaths, Czech Republic 2 confirmed cases and no death, Republic of Korea: 48 confirmed cases and no death, Dominican Republic : 91 confirmed cases, 1 death, Slovak Republic: 3 confirmed cases no death Romania: 9 confirmed cases no death, Russia: 3 confirmed cases and no deaths, Singapore: 18 confirmed cases and no deaths, Spain: 331 confirmed cases and no deaths, United States of America 13,217 U.S. confirmed and 27 deaths, Sweden: 16 confirmed cases and no deaths Switzerland: 16 confirmed cases and no death, Taipei 24 confirmed cases and no death, Thailand: 8 confirmed cases and no death, Trinidad and Tobago 2 confirmed cases and no deaths, Turkey: 10 confirmed cases and no, Ukraine 1 death confirmed case and no death, Hungary: 3 confirmed cases no death, Uruguay: 24 confirmed cases no deaths, Venezuela: 12 confirmed cases and no deaths, Vietnam: 15 confirmed cases and no death
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Sandoz Indonesia - Medical Information Officer
Sandoz Indonesia - Sandoz is a global generics leader. We save and improve lives by developing, producing and distributing high-quality, affordable pharmaceuticals. Thanks to our global network, Sandoz medicines are now available to 90% of people worldwide. In addition to direct cost savings to patients, we contribute to the stability of healthcare systems worldwide and free up resources for new and innovative medicines.
MEDICAL INFORMATION OFFICER
Under Training and Medical Manager’s supervision, the Medical Information Officer would be responsible for medical research, providing medical information and supports materials of a technical nature. The information will need to be referenced in accordance guidelines set by the Training & Medical manager and communicated in a professional and timely manner.MAJOR ACCOUNTABILITIES
- Collaborate with the Marketing/Business Development teams to establish their needs for medical-related references that are appropriate for our promoted products.
- Provide medical information required for products claims, promotions and communication materials.
- Build relationships with key medical professionals & institutions to ensure a good supply of quality information and resource materials.
- Assist the marketing teams in building close relationship with medical professions to improve the Sandoz brand image & credibility, ie. Attending scientific events as agreed with the line managers.
- Ensure that any marketing materials ( presentations, advertising, sales tools etc ) contain suitable and accurate medical information.
- Response promptly to scientific / medically enquiries from the sales or marketing team.
- Coordinate with the sales and marketing team in conducting product presentation (only function as the last resource) or medical training to field force.
- Assist Training and Medical Manager in developing basic medical knowledge during induction program or national training.
- Lead the assigned projects from Medical Manager (incl. PMS, local trials, etc).
- Support Medical Manager as the LPPV in handling ADR (adverse drug reactions).
REQUIREMENTS
- Educational: Medical Doctor, Bachelor in Physiology, Biology, Pharmacy, Nursing Care, or Physiotherapy
- Experience: 1-3 years experiences in medical or training department in pharmaceutical industry Experience in product management of pharmaceutical industry would be an additional advantage
- Technical Qualifications: Communication & Presentation skills as well as Medical nowledge
- Computer Qualifications: Microsoft Office (MS Words, Power Points, MS Excel, Internet Explorer, or Adobe)
- Language Qualification: English competency
Interested candidates are invited to email/ write in a comprehensive resume stating current/ last drawn and expected salary and date of availability together with a recent photograph to the following:
Email:
pramita.kamelia@sandoz.com
Mailing address:
PT. Sandoz Indonesia
Jl. T.B. Simatupang, Kp. Gedong
Pasar Rebo
Jakarta 13670
We regret that only short listed candidates will be notified
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